The Sequence of the Human Genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp ...
Publications
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443 publications
A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules
Abstract: We present the derivation of a new molecular mechanical force field for simulating the structures, conformational energies, and interaction energies of proteins, nucle...
<i>Planck</i> 2018 results
We present cosmological parameter results from the final full-mission Planck measurements of the cosmic microwave background (CMB) anisotropies, combining information from the t...
Global Consequences of Land Use
Land use has generally been considered a local environmental issue, but it is becoming a force of global importance. Worldwide changes to forests, farmlands, waterways, and air ...
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States
The prevalence of psychiatric disorders is greater than previously thought to be the case. Furthermore, this morbidity is more highly concentrated than previously recognized in ...
Representation Learning: A Review and New Perspectives
The success of machine learning algorithms generally depends on data representation, and we hypothesize that this is because different representations can entangle and hide more...
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
The problem of identifying differentially expressed genes in designed microarray experiments is considered. Lonnstedt and Speed (2002) derived an expression for the posterior od...
Significance analysis of microarrays applied to the ionizing radiation response
Microarrays can measure the expression of thousands of genes to identify changes in expression between different biological states. Methods are needed to determine the significa...
An application-specific protocol architecture for wireless microsensor networks
Networking together hundreds or thousands of cheap microsensor nodes allows users to accurately monitor a remote environment by intelligently combining the data from the individ...
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
<b><i>Background:</i></b> We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on th...