Helplessness: On Depression, Development, and Death
Overview - depression, golden girl, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability - voluntary responding, response independence and...
Publications
Explore 1,206 academic publications
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1,206 publications
Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a plat...
Cancer immunotherapy using checkpoint blockade
The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses i...
On the psychology of prediction.
In this paper, we explore the rules that determine intuitive predictions and judgments of confidence and contrast these rules to the normative principles of statistical predicti...
Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
Pembrolizumab had an acceptable side-effect profile and showed antitumor activity in patients with advanced non-small-cell lung cancer. PD-L1 expression in at least 50% of tumor...
Scaling Theory of Localization: Absence of Quantum Diffusion in Two Dimensions
Arguments are presented that the $T=0$ conductance $G$ of a disordered electronic system depends on its length scale $L$ in a universal manner. Asymptotic forms are obtained for...
Oxidants, antioxidants, and the degenerative diseases of aging.
Metabolism, like other aspects of life, involves tradeoffs. Oxidant by-products of normal metabolism cause extensive damage to DNA, protein, and lipid. We argue that this damage...