Detection of a SARS-CoV-2 variant of concern in South Africa
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newl...
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Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome
The DNA sequencing technologies in use today produce either highly accurate short reads or less-accurate long reads. We report the optimization of circular consensus sequencing ...
Immunology of COVID-19: Current State of the Science
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an u...
An oral SARS-CoV-2 M <sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19
Path to another drug against COVID-19 The rapid development of vaccines has been crucial in battling the ongoing COVID-19 pandemic. However, access challenges remain, breakthrou...
Molecular immune pathogenesis and diagnosis of COVID-19
Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of SARS-CoV-2 has...
LIO-SAM: Tightly-coupled Lidar Inertial Odometry via Smoothing and Mapping
We propose a framework for tightly-coupled lidar inertial odometry via smoothing and mapping, LIO-SAM, that achieves highly accurate, real-time mobile robot trajectory estimatio...
Fate of the false vacuum. II. First quantum corrections
It is possible for a classical field theory to have two homogeneous stable equilibrium states with different energy densities. In the quantum version of the theory, the state of...
ART: a next-generation sequencing read simulator
Abstract Summary: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools f...
Causes of Higher Climate Sensitivity in CMIP6 Models
Abstract Equilibrium climate sensitivity, the global surface temperature response to CO doubling, has been persistently uncertain. Recent consensus places it likely within 1.5–4...