A fast non-negativity-constrained least squares algorithm
In this paper a modification of the standard algorithm for non-negativity-constrained linear least squares regression is proposed. The algorithm is specifically designed for use...
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311 publications
Early Lactate-Guided Therapy in Intensive Care Unit Patients
In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consis...
Management of Lung Nodules Detected by Volume CT Scanning
Among subjects at high risk for lung cancer who were screened in three rounds of CT scanning and in whom noncalcified pulmonary nodules were evaluated according to volume and vo...
Where Does Parkinson Disease Pathology Begin in the Brain?
The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative st...
GAGE: A critical evaluation of genome assemblies and assembly algorithms
New sequencing technology has dramatically altered the landscape of whole-genome sequencing, allowing scientists to initiate numerous projects to decode the genomes of previousl...
Transient and Stable Expression of the Firefly Luciferase Gene in Plant Cells and Transgenic Plants
The luciferase gene from the firefly, Photinus pyralis , was used as a reporter of gene expression by light production in transfected plant cells and transgenic plants. A comple...
Late Glacial and Holocene vegetation history in the southern part of Transylvania (Romania): pollen analysis of two sequences from Avrig
Abstract We present here the results of pollen analysis of two sequences of about 8.06 m and 11.90 m length, originating from two adjacent peat bogs in the southern part of Tran...
Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations
Our study has identified key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCA2 genes. This information may improve the classification...
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial–mesenchymal transition
Expression of Snail1 in epithelial cells triggers an epithelial–mesenchymal transition (EMT). Here, we demonstrate that the synthesis of Zeb2, a transcriptional repressor of E-c...