Early Lactate-Guided Therapy in Intensive Care Unit Patients

Abstract

In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consistent with important secondary endpoints, this study suggests that initial lactate monitoring has clinical benefit. Clinical trial registered with www.clinicaltrials.gov (NCT00270673).

Keywords

MedicineHyperlactatemiaIntensive care unitConfidence intervalMechanical ventilationResuscitationHazard ratioPopulationIntensive careBlood lactateInternal medicineAnesthesiaIntensive care medicineBlood pressureHeart rate

Affiliated Institutions

Erasmus MC NL

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Publication Info

Year: 2010
Type: article
Volume: 182
Issue: 6
Pages: 752-761
Citations: 859
Access: Closed

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APA Style

                            
                                
                                    Tim C. Jansen, 
                                
                                    Jasper van Bommel, 
                                
                                    F J Schoonderbeek
                                
                                et al.
                            
                            (2010). 
                            Early Lactate-Guided Therapy in Intensive Care Unit Patients. 
                            American Journal of Respiratory and Critical Care Medicine
                            , 182
                            (6)
                            , 752-761.
                            https://doi.org/10.1164/rccm.200912-1918oc
                        

Identifiers

DOI: 10.1164/rccm.200912-1918oc