Publications

Ligation-independent cloning of PCR products (LIC-PCR)

A new procedure has been developed for the efficient cloning of complex PCR mixtures, resulting in libraries exclusively consisting of recombinant clones. Recombinants are gener...

A framework for the interpretation of de novo mutation in human disease

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Interleukin-6 (IL-6) is a pleiotropic cytokine, whose plasma levels are elevated in inflammatory diseases such as atherosclerosis. We have previously reported that peroxisome pr...

Potential effect of population and climate changes on global distribution of dengue fever: an empirical model

Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older

In our trial, HZ/su was found to reduce the risks of herpes zoster and postherpetic neuralgia among adults 70 years of age or older. (Funded by GlaxoSmithKline Biologicals; ZOE-...

The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing

Swarm: robust and fast clustering method for amplicon-based studies

Popular de novo amplicon clustering methods suffer from two fundamental flaws: arbitrary global clustering thresholds, and input-order dependency induced by centroid selection. ...

Genotype, haplotype and copy-number variation in worldwide human populations

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: baryon acoustic oscillations in the Data Release 9 spectroscopic galaxy sample

We present measurements of galaxy clustering from the Baryon Oscillation\nSpectroscopic Survey (BOSS), which is part of the Sloan Digital Sky Survey III\n(SDSS-III). These use t...

A fast non-negativity-constrained least squares algorithm

In this paper a modification of the standard algorithm for non-negativity-constrained linear least squares regression is proposed. The algorithm is specifically designed for use...

Early Lactate-Guided Therapy in Intensive Care Unit Patients

In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consis...