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An integrated encyclopedia of DNA elements in the human genome
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) pro...
Hierarchical Grouping to Optimize an Objective Function
Abstract A procedure for forming hierarchical groups of mutually exclusive subsets, each of which has members that are maximally similar with respect to specified characteristic...
Qualitative research and case study applications in education
THE DESIGN OF QUALITATIVE RESEARCH. 1. What is Qualitative Research? 2. Case Studies as Qualtitative Research. 3. Designing the Study and Selecting a Sample. COLLECTING QUALITAT...
MapReduce
MapReduce is a programming model and an associated implementation for processing and generating large datasets that is amenable to a broad variety of real-world tasks. Users spe...
New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0
PhyML is a phylogeny software based on the maximum-likelihood principle. Early PhyML versions used a fast algorithm performing nearest neighbor interchanges to improve a reasona...
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
Proteins and their functional interactions form the backbone of the cellular machinery. Their connectivity network needs to be considered for the full understanding of biologica...
Significance tests and goodness of fit in the analysis of covariance structures.
Factor analysis, path analysis, structural equation modeling, and related multivariate statistical methods are based on maximum likelihood or generalized least squares estimatio...
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China
This Viewpoint summarizes key epidemiologic and clinical findings from all cases of coronavirus disease 2019 (COVID-19) reported through February 11, 2020, in mainland China, an...
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
On the basis of this information, there is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019. Considerable efforts to...