The Gene Ontology resource: enriching a GOld mine
Abstract The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene produ...
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520 publications
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
BACKGROUND Nivolumab plus ipilimumab or nivolumab alone resulted in longer progression-free and overall survival than ipilimumab alone in a trial involving patients with advance...
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline
Purpose To increase awareness, outline strategies, and offer guidance on the recommended management of immune-related adverse events in patients treated with immune checkpoint i...
Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer
In patients with previously untreated metastatic, squamous NSCLC, the addition of pembrolizumab to chemotherapy with carboplatin plus paclitaxel or nab-paclitaxel resulted in si...
The biomass distribution on Earth
Significance The composition of the biosphere is a fundamental question in biology, yet a global quantitative account of the biomass of each taxon is still lacking. We assemble ...
Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma.
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hemat...