Publications

Early Lactate-Guided Therapy in Intensive Care Unit Patients

In patients with hyperlactatemia on ICU admission, lactate-guided therapy significantly reduced hospital mortality when adjusting for predefined risk factors. As this was consis...

Large-scale whole-genome sequencing of the Icelandic population

Protein Lipidation in Cell Signaling

The ability of cells to communicate with and respond to their external environment is critical for their continued existence. A universal feature of this communication is that t...

Cosmological implications of baryon acoustic oscillation measurements

Here, we derive constraints on cosmological parameters and tests of dark energy models from the combination of baryon acoustic oscillation (BAO) measurements with cosmic microwa...

The Influence of Hospital Volume on Survival after Resection for Lung Cancer

Patients who undergo resection for lung cancer at hospitals that perform large numbers of such procedures are likely to survive longer than patients who have such surgery at hos...

Prediction of Mortality and Morbidity With a 6-Minute Walk Test in Patients With Left Ventricular Dysfunction

<h3>Objective.</h3> —To study the potential usefulness of the 6-minute walk test, a self-paced submaximal exercise test, as a prognostic indicator in patients with left ventricu...

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of severa...

Simplified Therapeutic Intervention Scoring System

Objectives To validate a simplified version of the Therapeutic Intervention Scoring System, the TISS-28, and to determine the association of TISS-28 with the time spent on score...

Maternal Attachment

Abstract To determine whether present hospital practices may affect later maternal behavior, we placed 28 primiparous women in two study groups shortly after delivery of normal ...

Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET

The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during...

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type i...

Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy.

Of the 180 children admitted to hospitals in Tyneside in the first year of life with proved respiratory syncytial virus lower respiratory tract infection, 130 were seen for revi...