Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project
The SCORE risk estimation system offers direct estimation of total fatal cardiovascular risk in a format suited to the constraints of clinical practice.
Publications
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1,720 publications
A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance
Complex interventions are commonly used in the health and social care services, public health practice, and other areas of social and economic policy that have consequences for ...
Effects of Enalapril on Mortality in Severe Congestive Heart Failure
To evaluate the influence of the angiotensin-converting-enzyme inhibitor enalapril (2.5 to 40 mg per day) on the prognosis of severe congestive heart failure (New York Heart Ass...
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
We identified at least one potential driver mutation in nearly all AML samples and found that a complex interplay of genetic events contributes to AML pathogenesis in individual...
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, ...
New Perspectives in Cell Adhesion: RGD and Integrins
Rapid progress has been made in the understanding of the molecular interactions that result in cell adhesion. Many adhesive proteins present in extracellular matrices and in the...
The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial
In patients with heart failure, beta-blockade has improved morbidity and left-ventricular function, but the impact on survival is uncertain. We investigated the efficacy of biso...
Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38
State of the art simulations of aortic haemodynamics feature full fluid-structure interaction (FSI) and coupled 0D boundary conditions. Such analyses require not only significan...
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
OBJECTIVE—To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WH...