Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

M R Stearne , S L Palmer , M S Hammersley , M R Stearne , S L Palmer , M S Hammersley , S L Franklin , R S Spivey , J Lévy , C R Tidy , N J Bell , J Steemson , B. Barrow , R. De Coster , K Waring , James Nolan , Emily Truscott , N Walravens , L. S. Cook , H Lampard , Carole Merle , P Parker , Janet McVittie , I Draisey , Lilian E. Murchison , A H E Brunt , Mark J. Williams , D. Pearson , X M P Petrie , MEJ Lean , D. Walmsley , Marcus J. Lyall , Emily Christie , Jody Church , Emma C. Thomson , A Farrow , J. M. Stowers , M Stowers , K C McHardy , Noelle B. Patterson , Alex Wright , N A Levi , A Shearer , R J W Thompson , Glyn Taylor , S Rayton , M. W. B. Bradbury , A. Glover , A Smyth-Osbourne , Chad W. Parkes , John Graham , P England , S N Gyde , Craig Eagle , B Chakrabarti , James Smith , J Sherwell , Eva M. Kohner , A Dornhurst , M C Doddridge , Martin J. Dumskyj , Shahenaz Walji , P. S. Sharp , Marcus A. Sleightholm , Grace Vanterpool , Colin P. Rose , Gary Frost , M Roseblade , Simon Elliott , Sara Forrester , Michael B. Foster , K A Myers , Richard H. Chapman , John R. Hayes , Robert W. Henry , Marcelo Featherston , G P R Archbold , M Copeland , Roy Harper , I. M. Richardson , Stéphan Martin , H A Davison , D. R. Hadden , L. Kennedy , A. B. Atkinson , A M Culbert , C Hegan , H Tennet , Neil Webb , I. Robinson , John Holmes , P. M. Bell , David R. McCance , John D. Rutherford , Shawna D. Nesbitt , A S Spathis , Steve Hyer , M E Nanson , Linda James , J M Tyrell , Courtney Davis , P Strugnell , Marika Booth
1998 4,820 citations

Abstract

State of the art simulations of aortic haemodynamics feature full fluid-structure interaction (FSI) and coupled 0D boundary conditions. Such analyses require not only significant computational resource but also weeks to months of run time, which compromises the effectiveness of their translation to a clinical workflow. This article employs three computational fluid methodologies, of varying levels of complexity with coupled 0D boundary conditions, to simulate the haemodynamics within a patient-specific aorta. The most comprehensive model is a full FSI simulation. The simplest is a rigid walled incompressible fluid simulation while an alternative middle-ground approach employs a compressible fluid, tuned to elicit a response analogous to the compliance of the aortic wall. The results demonstrate that, in the context of certain clinical questions, the simpler analysis methods may capture the important characteristics of the flow field.

Keywords

MedicineBlood pressureDiabetes mellitusCaptoprilType 2 diabetesInternal medicineConfidence intervalSurgeryEndocrinology

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Publication Info

Year
1998
Type
article
Volume
317
Issue
7160
Pages
703-713
Citations
4820
Access
Closed

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M R Stearne, S L Palmer, M S Hammersley et al. (1998). Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. , 317 (7160) , 703-713. https://doi.org/10.1016/j.jbiomech.2011.11.041

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DOI
10.1016/j.jbiomech.2011.11.041