Tau is essential to β-amyloid-induced neurotoxicity
Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease, are the results of the pathological deposition of proteins normally present througho...
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259 publications
Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
CD28 (Tp44) is a human T-cell-specific homodimer surface protein that may participate in T-cell activation. We have isolated a cDNA clone encoding CD28 by a simple and highly ef...
Decline in Cardiovascular Mortality
If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and st...
Hypertension and the Pathogenesis of Atherosclerosis
Abstract Hypertension is a risk factor for the development of atherosclerosis, although the mechanisms have not been well elucidated. As the cellular and molecular mechanisms of...
Where Does Parkinson Disease Pathology Begin in the Brain?
The substantia nigra is not the induction site in the brain of the neurodegenerative process underlying Parkinson disease (PD). Instead, the results of this semi-quantitative st...
The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells
Abstract The emergence of a novel, highly pathogenic coronavirus, 2019-nCoV, in China, and its rapid national and international spread pose a global health emergency. Coronaviru...
Co‐Authorship in Management and Organizational Studies: An Empirical and Network Analysis*
In recent decades there has been growing interest in the nature and scale of scientific collaboration. Studies into co‐authorship have taken two different approaches. The first ...
BEAGLE: An Application Programming Interface and High-Performance Computing Library for Statistical Phylogenetics
Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest i...
The Relative Operating Characteristic in Psychology
The clinician looking, listening, or feeling for signs of a disease may far prefer a false alarm to a miss, particularly if the disease is serious and contagious. On the other h...
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis† ‡
Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease for which there is no known effective therapy. A proportion of patients with NASH progress to advanced fibr...
Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)
Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau P301L )4510 mouse expresses the P301L mutation in tau (4R0N) associated with f...