Why yeast cells can undergo apoptosis: death in times of peace, love, and war

Sabrina Büttner; Tobias Eisenberg; Eva Herker; Didac Carmona‐Gutiérrez; Guido Kroemer; Frank Madeo

doi:10.1083/jcb.200608098

Abstract

The purpose of apoptosis in multicellular organisms is obvious: single cells die for the benefit of the whole organism (for example, during tissue development or embryogenesis). Although apoptosis has also been shown in various microorganisms, the reason for this cell death program has remained unexplained. Recently published studies have now described yeast apoptosis during aging, mating, or exposure to killer toxins (Fabrizio, P., L. Battistella, R. Vardavas, C. Gattazzo, L.L. Liou, A. Diaspro, J.W. Dossen, E.B. Gralla, and V.D. Longo. 2004. J. Cell Biol. 166:1055–1067; Herker, E., H. Jungwirth, K.A. Lehmann, C. Maldener, K.U. Frohlich, S. Wissing, S. Buttner, M. Fehr, S. Sigrist, and F. Madeo. 2004. J. Cell Biol. 164:501–507, underscoring the evolutionary benefit of a cell suicide program in yeast and, thus, giving a unicellular organism causes to die for.

Keywords

Multicellular organismYeastApoptosisOrganismProgrammed cell deathBiologyCellCell biologyMatingGenetics

MeSH Terms

AdaptationPhysiologicalApoptosisFoodMycotoxinsReactive Oxygen SpeciesSaccharomyces cerevisiae

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Publication Info

Year: 2006
Type: review
Volume: 175
Issue: 4
Pages: 521-525
Citations: 190
Access: Closed

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APA Style

                            
                                
                                    Sabrina Büttner, 
                                
                                    Tobias Eisenberg, 
                                
                                    Eva Herker
                                
                                et al.
                            
                            (2006). 
                            Why yeast cells can undergo apoptosis: death in times of peace, love, and war. 
                            The Journal of Cell Biology
                            , 175
                            (4)
                            , 521-525.
                            https://doi.org/10.1083/jcb.200608098
                        

Identifiers

DOI: 10.1083/jcb.200608098
PMID: 17101700
PMCID: PMC2064587

Data Quality

Data completeness: 86%