Abstract
Allele scores enable valid causal estimates with large numbers of genetic variants. The stringency of criteria for genetic variants in Mendelian randomization should be maintained for all variants in an allele score.
Keywords
Mendelian randomizationInstrumental variableAlleleGeneticsSample size determinationAllele frequencyStatisticsAdditive genetic effectsBiologyMathematicsGenetic variantsGenotypeHeritabilityGene
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Publication Info
- Year
- 2013
- Type
- article
- Volume
- 42
- Issue
- 4
- Pages
- 1134-1144
- Citations
- 469
- Access
- Closed
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Cite This
Stephen Burgess,
Simon G. Thompson
(2013).
Use of allele scores as instrumental variables for Mendelian randomization.
International Journal of Epidemiology
, 42
(4)
, 1134-1144.
https://doi.org/10.1093/ije/dyt093
Identifiers
- DOI
- 10.1093/ije/dyt093