Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)

Darren A. Natale; Uma Shankavaram; Michael Y. Galperin; Yuri I. Wolf; L. Aravind; Eugene V. Koonin

doi:10.1186/gb-2000-1-5-research0009

Abstract

Special-purpose databases organized on the basis of phylogenetic analysis and carefully curated with respect to known and predicted protein functions provide for a significant improvement in genome annotation. A differential genome display approach helps in a systematic investigation of common and distinct features of gene repertoires and in some cases reveals unexpected connections that may be indicative of functional similarities between phylogenetically distant organisms and of lateral gene exchange.

Keywords

BiologyCrenarchaeotaGenomeGeneticsComputational biologyArchaeaPhylumWhole genome sequencingGene

Affiliated Institutions

National Institutes of Health US

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Publication Info

Year: 2000
Type: article
Volume: 1
Issue: 5
Pages: RESEARCH0009-RESEARCH0009
Citations: 145
Access: Closed

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APA Style

                            
                                
                                    Darren A. Natale, 
                                
                                    Uma Shankavaram, 
                                
                                    Michael Y. Galperin
                                
                                et al.
                            
                            (2000). 
                            Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs). 
                            Genome biology
                            , 1
                            (5)
                            , RESEARCH0009-RESEARCH0009.
                            https://doi.org/10.1186/gb-2000-1-5-research0009
                        

Identifiers

DOI: 10.1186/gb-2000-1-5-research0009