Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

Abstract

As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; alteplase was more frequently associated with symptomatic intracranial hemorrhage. (ClinicalTrials.gov number, NCT00153036.)

Keywords

MedicineThrombolysisStroke (engine)Ischemic strokeAcute strokeFibrinolytic agentTissue plasminogen activatorEmergency medicineAnesthesiaInternal medicineIschemiaMyocardial infarction

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Publication Info

Year: 2008
Type: article
Volume: 359
Issue: 13
Pages: 1317-1329
Citations: 6420
Access: Closed

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APA Style

                            
                                
                                    Werner Hacke, 
                                
                                    Markku Kaste, 
                                
                                    Erich Bluhmki
                                
                                et al.
                            
                            (2008). 
                            Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. 
                            New England Journal of Medicine
                            , 359
                            (13)
                            , 1317-1329.
                            https://doi.org/10.1056/nejmoa0804656
                        

Identifiers

DOI: 10.1056/nejmoa0804656