The Status of the Gene Map of the Human Chromosomes

Victor A. McKusick; Frank H. Ruddle

doi:10.1126/science.850784

Abstract

In man, the specific chromosome that carries each of about 210 gene loci is known. These loci include at least one assigned to each chromosome (including the Y), about 110 assigned to specific autosomes, and about 100 to the X chromosome. For many loci, information on regional chromosomal localization is also available. The information comes mainly from studies in families and somatic cell hybrids, as well as an integration of results from the two methods. Knowledge of the chromosome map gives insight into evolution, chromosomal organization in relation to genetic control mechanisms, and the pathogenesis of neoplasms and malformations. Furthermore, it is useful in prenatal or premorbid diagnosis of hereditary diseases.

Keywords

GeneBiologyGeneticsEvolutionary biologyComputational biologyHuman genomeGene mappingGenomeChromosome

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Publication Info

Year: 1977
Type: article
Volume: 196
Issue: 4288
Pages: 390-405
Citations: 341
Access: Closed

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APA Style

                            
                                    Victor A. McKusick, 
                                
                                    Frank H. Ruddle
                                
                            (1977). 
                            The Status of the Gene Map of the Human Chromosomes. 
                            Science
                            , 196
                            (4288)
                            , 390-405.
                            https://doi.org/10.1126/science.850784

Identifiers

DOI: 10.1126/science.850784