Stanley R. Hamilton

Incidence and functional consequences of <i>hMLH1</i> promoter hypermethylation in colorectal carcinoma

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG...

Histopathological Identification of Colon Cancer with Microsatellite Instability

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

Previous studies have demonstrated that allelic deletions of the short arm of chromosome 17 occur in over 75% of colorectal carcinomas. Twenty chromosome 17p markers were used t...

Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions,...

Clues to the Pathogenesis of Familial Colorectal Cancer

A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of spo...

SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium