The Promise of Comparative Genomics in Mammals

Stephen J. O’Brien; Marilyn Menotti‐Raymond; William J. Murphy; Will Nash; Johannes Wienberg; Roscoe Stanyon; Jennifer A. Marshall Graves

doi:10.1126/science.286.5439.458

Abstract

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

Keywords

BiologyGenomicsGenomeComparative genomicsGeneComputational biologyGeneticsEvolutionary biologyFunctional genomics

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Publication Info

Year: 1999
Type: article
Volume: 286
Issue: 5439
Pages: 458-481
Citations: 422
Access: Closed

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APA Style

                            
                                
                                    Stephen J. O’Brien, 
                                
                                    Marilyn Menotti‐Raymond, 
                                
                                    William J. Murphy
                                
                                et al.
                            
                            (1999). 
                            The Promise of Comparative Genomics in Mammals. 
                            Science
                            , 286
                            (5439)
                            , 458-481.
                            https://doi.org/10.1126/science.286.5439.458
                        

Identifiers

DOI: 10.1126/science.286.5439.458