Abstract

Promyelocytic leukemia (PML) nuclear bodies have been implicated in a variety of cellular processes including apoptosis, tumour suppression, anti-viral response, DNA repair and transcriptional regulation. PML nuclear bodies are both positionally and structurally stable over extended periods of interphase. As demonstrated in this study, the structural stability is lost as cells enter S phase, evidenced both by distortions in shape and by fission and fusion events. At the end of this period of structural instability, the number of PML nuclear bodies has increased by a factor of twofold. Association of the fission products with chromatin implies that the PML nuclear bodies respond to changes in chromatin organisation or topology, and thus could play a role in monitoring genome integrity during DNA synthesis or in the continued maintenance of functional chromosomal domains prior to mitosis.

Keywords

BiologyChromatinInterphaseMitosisCell biologyNuclear proteinPromyelocytic leukemia proteinCell nucleusDNADNA damageFissionCell cycleGeneticsTranscription factorCytoplasmApoptosisGenePhysicsNuclear physics

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Year
2006
Type
article
Volume
119
Issue
6
Pages
1026-1033
Citations
98
Access
Closed

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Graham Dellaire, Reagan W. Ching, Hesam Dehghani et al. (2006). The number of PML nuclear bodies increases in early S phase by a fission mechanism. Journal of Cell Science , 119 (6) , 1026-1033. https://doi.org/10.1242/jcs.02816

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DOI
10.1242/jcs.02816