Hospital for Sick Children

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

Abstract The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the...

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both

The number of published systematic reviews of studies of healthcare interventions has increased rapidly and these are used extensively for clinical and policy decisions. Systema...

Identification of human brain tumour initiating cells

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

In this global study of CAR T-cell therapy, a single infusion of tisagenlecleucel provided durable remission with long-term persistence in pediatric and young adult patients wit...

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

<scp>I</scp>nternational <scp>S</scp>ociety of <scp>N</scp>europathology‐<scp>H</scp>aarlem <scp>C</scp>onsensus <scp>G</scp>uidelines for <scp>N</scp>ervous <scp>S</scp>ystem <scp>T</scp>umor <scp>C</scp>lassification and <scp>G</scp>rading

Abstract Major discoveries in the biology of nervous system tumors have raised the question of how non‐histological data such as molecular information can be incorporated into t...

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading

Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent...