The molecular machinery of regulated cell death

Abstract

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.

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Affiliated Institutions

• Ghent University BE
• Université Paris Cité FR
• Guangzhou University CN
• The University of Texas Southwestern Medical Center US
• University of Antwerp BE
• Karolinska University Hospital SE
• Centre de Recherche des Cordeliers FR
• Sorbonne Université FR
• Sorbonne Paris Cité FR
• Hôpital Européen Georges-Pompidou FR

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