Xin Jin

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

The coordinate regulation of the p53 and mTOR pathways in cells

Cell growth and proliferation requires an intricate coordination between the stimulatory signals arising from nutrients and growth factors and the inhibitory signals arising fro...

Role of Autophagy in Cancer: Management of Metabolic Stress

Human breast, ovarian, and prostate tumors display allelic loss of the essential autophagy gene beclin1 with high frequency, and an increase in the incidence of tumor formation ...

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

The biochemical properties of beclin 1 suggest a role in two fundamentally important cell biological pathways: autophagy and apoptosis. We show here that beclin 1 -/- mutant mic...

Autophagy Regulates Ageing in<i>C. elegans</i>

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian ...