Abstract

▪ Abstract Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases. In turn, these cause the recruitment of mediators of cell growth, of resistance to apoptosis, and of gene activation and differentiation. Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various mechanisms through which receptor function is modulated. We particularly emphasize the modular nature of the receptor and the specialization of different receptor regions for distinct functions, most notably the independent regulation of cell growth and gene activation.

Keywords

BiologyInterleukin-21 receptorCommon gamma chainCell biologySignal transductionReceptor5-HT5A receptorImmune receptorCytokine receptorInterleukin-13 receptorInterleukin-1 receptorCytokineImmunologyInsulin-like growth factor 1 receptorGeneticsInterleukinGrowth factor

MeSH Terms

Amino Acid SequenceAnimalsCalcium-Calmodulin-Dependent Protein KinasesHumansInsulin Receptor Substrate ProteinsInterleukin-4Intracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMiceMiceKnockoutMitogen-Activated Protein KinasesMolecular Sequence DataPhosphoproteinsProtein Tyrosine PhosphatasesReceptorsInterleukin-4STAT6 Transcription FactorSignal TransductionTrans-Activators

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Publication Info

Year
1999
Type
review
Volume
17
Issue
1
Pages
701-738
Citations
1531
Access
Closed

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Cite This

Keats Nelms, Achsah Keegan, José Luís Zamorano et al. (1999). THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions. Annual Review of Immunology , 17 (1) , 701-738. https://doi.org/10.1146/annurev.immunol.17.1.701

Identifiers

DOI
10.1146/annurev.immunol.17.1.701
PMID
10358772

Data Quality

Data completeness: 81%