Keywords
BiologyCancerComputational biologyGenetics
MeSH Terms
AnimalsApoptosisCell TransformationNeoplasticGene Expression RegulationNeoplasticHumansNeoplasmsNeoplasmsExperimentalNeovascularizationPathologic
Affiliated Institutions
Related Publications
Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.
In the therapy of various kinds of tumors, methylating agents generating O6-methylguanine (O6MeG) in DNA are used. We studied the molecular mechanism of cell death induced by th...
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxicstress is only par...
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
Double-stranded DNA breaks (DSBs) trigger p53-mediated cell cycle arrest or apoptosis pathways that limit the oncogenic consequences of exposure to genotoxic agents, but p53-med...
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
Human diploid fibroblast cells lose replicative potential after a certain number of population doublings. We use this experimental system to investigate the role of oxidative da...
Publication Info
- Year
- 2000
- Type
- review
- Volume
- 100
- Issue
- 1
- Pages
- 57-70
- Citations
- 28162
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
28162
OpenAlex
41
Influential
22455
CrossRef
Cite This
Douglas Hanahan,
Robert A. Weinberg
(2000).
The Hallmarks of Cancer.
Cell
, 100
(1)
, 57-70.
https://doi.org/10.1016/s0092-8674(00)81683-9
Identifiers
- DOI
- 10.1016/s0092-8674(00)81683-9
- PMID
- 10647931