The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

Abstract

Cutaneous leishmaniasis is a neglected tropical disease, broadly distributed in the planet and with high incidence among socially vulnerable persons. It has been underestimated by healthcare systems and society, with a great burden of disease. Despite an available effective and well established treatment since the 50’s, it has been documented an increasing rate of resistance and treatment failure. Reports in Latin America, show resistance rates between 10-20% and 25% of subjects with treatment failure using first line drugs. Nevertheless, there is no clear association between reduced in vitro susceptibility from the parasite and treatment response.
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\nThis case control study with 34 subjects in a reference center in Bogotá, aimed to establish an association between reduced in vitro susceptibility and response to treatment. The results showed an OR 0.71 (IC 95% 0.085 – 9.39), which possibly means that there is no relation among the mentioned variables.
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\nThese results suggest that susceptibility testing would not impact clinical decision making as treatment failure predictors, therefore limiting its systematic use

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Affiliated Institutions

• Texas A&M University US
• Vector Control Research Centre IN
• London School of Hygiene & Tropical Medicine GB
• Watford General Hospital GB
• Stanford University US
• Institut de Recherche pour le Développement FR
• Institute for Health Metrics and Evaluation US
• Inovio Pharmaceuticals (United States) US
• Texas Children's Hospital US
• Brandeis University US
• Imperial College London GB
• University of Liverpool GB
• Case Western Reserve University US
• Rice University US
• Swiss Tropical and Public Health Institute CH
• University of Basel CH
• University of Washington US
• Johns Hopkins University US
• University of Oklahoma Health Sciences Center US
• Anglia Ruskin University GB
• Erasmus MC NL
• International Livestock Research Institute KE
• Baylor College of Medicine US
• Sabin Vaccine Institute US

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