Abstract

The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids, different taxa of Lachnospiraceae are also associated with different intra- and extraintestinal diseases. Their impact on the host physiology is often inconsistent across different studies. Here, we discuss changes in Lachnospiraceae abundances according to health and disease. With the aim of harnessing Lachnospiraceae to promote human health, we also analyze how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology.

Keywords

LachnospiraceaeBiologyHost (biology)Gut floraDiseaseHuman healthPhysiologyEcologyBiochemistryInternal medicineMedicineEnvironmental healthGene

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Publication Info

Year
2020
Type
review
Volume
8
Issue
4
Pages
573-573
Citations
1519
Access
Closed

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Cite This

Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese et al. (2020). The Controversial Role of Human Gut Lachnospiraceae. Microorganisms , 8 (4) , 573-573. https://doi.org/10.3390/microorganisms8040573

Identifiers

DOI
10.3390/microorganisms8040573
PMID
32326636
PMCID
PMC7232163

Data Quality

Data completeness: 81%