Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Matthew R. Janes; Jingchuan Zhang; Lian‐Sheng Li; Rasmus Hansen; Ulf Peters; Xin Guo; Yuching Chen; Anjali Babbar; Sarah J. Firdaus; Levan Darjania; Jun Feng; Jeffrey H. Chen; Shuangwei Li; Shisheng Li; Yun Oliver Long; Carol Thach; Yuan Liu; Ata Zarieh; Tess Ely; Jeff Kucharski; Linda Kessler; Tao Wu; Ke Yu; Yi Wang; Yvonne Yao; Xiaohu Deng; Patrick P. Zarrinkar; Dirk Brehmer; Dashyant Dhanak; Matthew V. Lorenzi; Dana D. Hu‐Lowe; Matthew P. Patricelli; Pingda Ren; Yi Liu

doi:10.1016/j.cell.2018.01.006

Keywords

KRASDruggabilityIn vivoBiologyMutantAllosteric regulationCancer researchGTP'In vitroMutationCell biologyComputational biologyPharmacologyBiochemistryGeneticsEnzymeGene

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Publication Info

Year: 2018
Type: article
Volume: 172
Issue: 3
Pages: 578-589.e17
Citations: 1110
Access: Closed

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APA Style

                            
                                
                                    Matthew R. Janes, 
                                
                                    Jingchuan Zhang, 
                                
                                    Lian‐Sheng Li
                                
                                et al.
                            
                            (2018). 
                            Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. 
                            Cell
                            , 172
                            (3)
                            , 578-589.e17.
                            https://doi.org/10.1016/j.cell.2018.01.006
                        

Identifiers

DOI: 10.1016/j.cell.2018.01.006