Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

Perrine Castets; Shuo Lin; Nathalie Rion; Sabrina Di Fulvio; Klaas Romanino; Maitea Guridi; Stephan Frank; Lionel Tintignac; Michael Sinnreich; Markus A. Rüegg

doi:10.1016/j.cmet.2013.03.015

Keywords

mTORC1AutophagyMyopathyStarvationSkeletal muscleCell biologyBiologyEndocrinologyGeneticsSignal transductionPI3K/AKT/mTOR pathway

Affiliated Institutions

Related Publications

The coordinate regulation of the p53 and mTOR pathways in cells

Zhaohui Feng , Haiyan Zhang , Arnold J. Levine +1 more

Cell growth and proliferation requires an intricate coordination between the stimulatory signals arising from nutrients and growth factors and the inhibitory signals arising fro...

2005 Proceedings of the National Academy o... 1214 citations

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Chang Hwa Jung , Chang Jun , Seung‐Hyun Ro +5 more

Autophagy, the starvation-induced degradation of bulky cytosolic components, is up-regulated in mammalian cells when nutrient supplies are limited. Although mammalian target of ...

2009 Molecular Biology of the Cell 1948 citations

Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival

Xiantao Wang , Karen D. McCullough , Thomas Franke +1 more

The serine/threonine kinase Akt (also known as protein kinase B) is activated in response to various stimuli by a mechanism involving phosphoinositide 3-kinase (PI3-K). Akt prov...

2000 Journal of Biological Chemistry 459 citations

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Nao Hosokawa , Taichi Hara , Takeshi Kaizuka +10 more

Autophagy is an intracellular degradation system, by which cytoplasmic contents are degraded in lysosomes. Autophagy is dynamically induced by nutrient depletion to provide nece...

2009 Molecular Biology of the Cell 1986 citations

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ian G. Ganley , Du Lam , Junru Wang +3 more

Autophagy is a degradative process that recycles long-lived and faulty cellular components. It is linked to many diseases and is required for normal development. ULK1, a mammali...

2009 Journal of Biological Chemistry 1501 citations

Publication Info

Year: 2013
Type: article
Volume: 17
Issue: 5
Pages: 731-744
Citations: 288
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

288

OpenAlex

Cite This

APA Style

                            
                                
                                    Perrine Castets, 
                                
                                    Shuo Lin, 
                                
                                    Nathalie Rion
                                
                                et al.
                            
                            (2013). 
                            Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy. 
                            Cell Metabolism
                            , 17
                            (5)
                            , 731-744.
                            https://doi.org/10.1016/j.cmet.2013.03.015
                        

Identifiers

DOI: 10.1016/j.cmet.2013.03.015