Supplementary Figure from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li; Baishan Jiang; Jiaye Guo; Shao Hong; Isabella Del Priore; Qing Chang; Rei Kudo; Zhiqiang Li; Pedram Razavi; Bo Liu; Andrew S. Boghossian; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Katherine A. Donovan; Marta Palafox; Jorge S. Reis‐Filho; Elisa de Stanchina; Eric S. Fischer; Neal Rosen; Violeta Serra; Andrew Koff; John D. Chodera; Nathanael S. Gray; Sarat Chandarlapaty

doi:10.1158/2159-8290.30834160

Abstract

Supplementary Figure from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Related Publications

Acquired Resistance to Epidermal Growth Factor Receptor Kinase Inhibitors Associated with a Novel T854A Mutation in a Patient with <i>EGFR</i>-Mutant Lung Adenocarcinoma

James Bean , Gregory J. Riely , Marissa N. Balak +4 more

Abstract Purpose: Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are associated with sensitivity of lung adenocarcinomas to ...

2008 Clinical Cancer Research 276 citations

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

Jessie Villanueva , Adina Vultur , John Tayu Lee +18 more

BRAF is an attractive target for melanoma drug development. However, resistance to BRAF inhibitors is a significant clinical challenge. We describe a model of resistance to BRAF...

2010 Cancer Cell 1218 citations

Opportunities and challenges in the development of kinase inhibitor therapy for cancer

Charles L. Sawyers

The success of the tyrosine kinase imatinib inhibitor (Gleevec, STI571) in treating chronic myeloid leukemia as well as other selected cancers has greatly increased optimism for...

2003 Genes & Development 169 citations

Targeting PI3K in cancer: mechanisms and advances in clinical trials

Jing Yang , Ji Nie , Xuelei Ma +3 more

Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master ...

2019 Molecular Cancer 1491 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

M Debbas , Eileen White

Transformation of primary rodent cells by the adenovirus E1A and E1B oncogenes is a two-step process, where E1A-dependent induction of proliferation is coupled to E1B-dependent ...

1993 Genes & Development 873 citations

Publication Info

Year: 2025
Type: article
Citations: 0
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Supplementary Figure from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                    Qing Li, 
                                
                                    Baishan Jiang, 
                                
                                    Jiaye Guo
                                
                                et al.
                            
                            (2025). 
                            Supplementary Figure from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors. 
                            
                            .
                            https://doi.org/10.1158/2159-8290.30834160

Identifiers

DOI: 10.1158/2159-8290.30834160