Publications
4 shownRAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
Tumours with mutant BRAF are dependent on the RAF–MEK–ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells with ...
Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
Abstract Selumetinib (AZD6244, ARRY-142886) is a selective, non–ATP-competitive inhibitor of mitogen-activated protein/extracellular signal–regulated kinase kinase (MEK)-1/2. Th...
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK) inhibitors. In contr...
Frequent Co-Authors
Researcher Info
- h-index
- 4
- Publications
- 4
- Citations
- 3,792
- Institution
- Memorial Sloan Kettering Cancer Center
External Links
Identifiers
- ORCID
- 0000-0002-8307-654X
Impact Metrics
h-index
4
h-index: Number of publications with at least h citations each.