Abstract
The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.
Keywords
BiologyGenomeGeneENCODEString (physics)Computational biologyGeneticsContext (archaeology)Neighbourhood (mathematics)
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Publication Info
- Year
- 2000
- Type
- article
- Volume
- 28
- Issue
- 18
- Pages
- 3442-3444
- Citations
- 1235
- Access
- Closed
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Cite This
Berend Snel
(2000).
STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene.
Nucleic Acids Research
, 28
(18)
, 3442-3444.
https://doi.org/10.1093/nar/28.18.3442
Identifiers
- DOI
- 10.1093/nar/28.18.3442