Abstract

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.

Keywords

ENCODEBiologyHuman genomeEncyclopediaGenomeComputational biologyGeneticsGenome projectGeneData scienceComputer science

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Publication Info

Year
2011
Type
article
Volume
9
Issue
4
Pages
e1001046-e1001046
Citations
1557
Access
Closed

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The ENCODE Project Consortium (2011). A User's Guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biology , 9 (4) , e1001046-e1001046. https://doi.org/10.1371/journal.pbio.1001046

Identifiers

DOI
10.1371/journal.pbio.1001046