Stressful life events, genetic liability, and onset of an episode of major depression in women

Abstract

Genetic factors influence the risk of onset of major depression in part by altering the sensitivity of individuals to the depression-inducing effect of stressful life events.

Keywords

Depression (economics)Twin studyPsychologyPopulationMonozygotic twinOdds ratioEtiologyPsychiatryMedicineDemographyClinical psychologyInternal medicineGeneticsBiologyHeritability

Affiliated Institutions

Virginia Commonwealth University Medical Center US

Related Publications

Individual differences are accentuated during periods of social change: The sample case of girls at puberty.

Avshalom Caspi , Terrie E. Moffitt

The emergence of new behaviors and the reorganization of psychological structures are often attributed to critical events and crises in the life course. A fundamentally differen...

1991 Journal of Personality and Social Psy... 395 citations

Helplessness: On Depression, Development, and Death

Martin E. P. Seligman

Overview - depression, golden girl, anxiety and unpredictability, childhood failure, sudden psychosomatic death controllability - voluntary responding, response independence and...

1975 CERN Document Server (European Organi... 6270 citations

The Familial Transmission of Bipolar Illness

John P. Rice , Theodore Reich , Nancy C. Andreasen +5 more

As part of the National Institute of Mental Health Collaborative Program on the Psychobiology of Depression study, data were collected on 2225 first-degree relatives of 612 prob...

1987 Archives of General Psychiatry 356 citations

Comparability and Sensitivity of Set 2 (Lists E, F, and G) of the Depression Adjective Check Lists

Bernard Lubin , Vladimir A. Dupre , Alice W. Lubin

To test the comparability of Set 2 (Lists E, F, and G) of the Depression Adjective Check Lists (DACL), 74 Ss who participated in a 1-wk. sensitivity group conference were given ...

1967 Psychological Reports 15 citations

The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

Peter McGuffin , Frühling Rijsdijk , Martin Andrew +3 more

As defined by the DSM-IV, BPD is highly heritable. There are substantial genetic and nonshared environmental correlations between mania and depression, but most of the genetic v...

2003 Archives of General Psychiatry 1220 citations

Publication Info

Year: 1995
Type: article
Volume: 152
Issue: 6
Pages: 833-842
Citations: 1053
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Stressful life events, genetic liability, and onset of an episode of major depression in women

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1053

OpenAlex

Cite This

APA Style

                            
                                
                                    Kenneth S. Kendler, 
                                
                                    Ronald C. Kessler, 
                                
                                    Ellen E. Walters
                                
                                et al.
                            
                            (1995). 
                            Stressful life events, genetic liability, and onset of an episode of major depression in women. 
                            American Journal of Psychiatry
                            , 152
                            (6)
                            , 833-842.
                            https://doi.org/10.1176/ajp.152.6.833
                        

Identifiers

DOI: 10.1176/ajp.152.6.833