Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease

Abstract

Simvastatin plus niacin provides marked clinical and angiographically measurable benefits in patients with coronary disease and low HDL levels. The use of antioxidant vitamins in this setting must be questioned.

Keywords

NiacinSimvastatinMedicineInternal medicinePlaceboAntioxidantB vitaminsCholesterolGastroenterologyPharmacologyEndocrinologyBiochemistryPathologyChemistry

MeSH Terms

AntioxidantsApolipoproteinsAscorbic AcidCardiovascular DiseasesCholesterolHDLCholesterolLDLCoronary AngiographyCoronary DiseaseCoronary StenosisDouble-Blind MethodDrug InteractionsDrug TherapyCombinationFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLipidsMaleMiddle AgedNiacinSeleniumSimvastatinVitamin Ealpha-Tocopherolbeta Carotene

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Publication Info

Year: 2001
Type: article
Volume: 345
Issue: 22
Pages: 1583-1592
Citations: 1982
Access: Closed

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APA Style

                            
                                
                                    Bryan Brown, 
                                
                                    Xue-Qiao Zhao, 
                                
                                    Alan Chait
                                
                                et al.
                            
                            (2001). 
                            Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease. 
                            New England Journal of Medicine
                            , 345
                            (22)
                            , 1583-1592.
                            https://doi.org/10.1056/nejmoa011090
                        

Identifiers

DOI: 10.1056/nejmoa011090
PMID: 11757504

Data Quality

Data completeness: 86%