Signals from chloroplasts converge to regulate nuclear gene expression.

Shai Koussevitzky; Ajit Nott; Todd C. Mockler; Fangxin Hong; Gilberto Sachetto‐Martins; Marci Surpin; Jason Lim; Ron Mittler; Joanne Chory

doi:10.1126/science.1140516

Abstract

Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with chloroplast function and is essential for the photoautotrophic life-style of plants. Three retrograde signals have been described, but little is known of their signaling pathways. We show here that GUN1, a chloroplast-localized pentatricopeptide-repeat protein, and ABI4, an Apetala 2 (AP2)–type transcription factor, are common to all three pathways. ABI4 binds the promoter of a retrograde-regulated gene through a conserved motif found in close proximity to a light-regulatory element. We propose a model in which multiple indicators of aberrant plastid function in <i>Arabidopsis</i> are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes.

Keywords

Retrograde signalingPlastidPentatricopeptide repeatArabidopsisChloroplastNuclear geneGeneTranscription factorBiologyPsychological repressionGeneticsCell biologyFunction (biology)Computational biologyGenomeGene expressionMutant

Affiliated Institutions

Related Publications

Photosynthesis-Associated Gene Families: Differences in Response to Tissue-Specific and Environmental Factors

June Simpson , Marc Van Montagu , Luís Herrera‐Estrella

The endogenous small subunit of the ribulose-1,5-bisphosphate carboxylase gene rbcS and the light-harvesting chlorophyll a/b-binding protein gene ( LHCP ) of pea are expressed i...

1986 Science 173 citations

Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression

Paul R. Mittelstadt , Jonathan D. Ashwell

Activation-induced transcriptional upregulation of the ligand for Fas (FasL) and the resulting apoptosis of Fas-bearing cells constitute essential steps in a host of normal and ...

1998 Molecular and Cellular Biology 163 citations

Requirement for STAT1 in LPS-induced gene expression in macrophages

Yoshihiro Ohmori , Thomas A. Hamilton

Abstract This study examines the role of the signal transducer and activator of transcription 1 (STAT1) in induction of lipopolysaccharide (LPS)-stimulated gene expression both ...

2001 Journal of Leukocyte Biology 264 citations

Identification of Two Major Sites in the Type I Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways

Jennifer L. Slack , Kenneth Schooley , Timothy P. Bonnert +4 more

Type I interleukin-1 receptor is the prototype for a family of proteins, which play a central role in early responses to injury and infection. The similarity of function across ...

2000 Journal of Biological Chemistry 303 citations

Repression of the basal c-fos promoter by wild-type p53

Nikolai Kley , Richard Y. Chung , Sandra Fay +2 more

Mutations in the p53 gene are the most common genetic alterations observed in many inherited and sporadic forms of human cancer. Recent studies indicate that wild-type p53 may b...

1992 Nucleic Acids Research 90 citations

Publication Info

Year: 2007
Type: article
Volume: 316
Issue: 5825
Pages: 715-9
Citations: 5668
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Signals from chloroplasts converge to regulate nuclear gene expression.

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

5668

OpenAlex

Cite This

APA Style

                            
                                
                                    Shai Koussevitzky, 
                                
                                    Ajit Nott, 
                                
                                    Todd C. Mockler
                                
                                et al.
                            
                            (2007). 
                            Signals from chloroplasts converge to regulate nuclear gene expression.. 
                            PubMed
                            , 316
                            (5825)
                            , 715-9.
                            https://doi.org/10.1126/science.1140516
                        

Identifiers

DOI: 10.1126/science.1140516