Abstract

Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed. Newly established antibodies against Klotho allowed the detection of secreted Klotho, a candidate for the putative humoral factor, in sera and cerebrospinal fluid. Surprisingly the secreted Klotho was 130 kDa, in contrast to the 70 kDa predicted form from klotho gene transcripts. The secreted as well as the membrane‐bound Klotho proteins were suggested to form oligomerized complex. These results delineate post‐translation processing of Klotho and possible regulatory mechanisms for secretion of Klotho in vivo.

Keywords

KlothoSecretionBiologyPhenotypeMembrane proteinCell biologyGeneEndocrinologyBiochemistryKidneyMembrane

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Year
2004
Type
article
Volume
565
Issue
1-3
Pages
143-147
Citations
519
Access
Closed

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Akihiro Imura, Akiko Iwano, Osamu Tohyama et al. (2004). Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane. FEBS Letters , 565 (1-3) , 143-147. https://doi.org/10.1016/j.febslet.2004.03.090

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DOI
10.1016/j.febslet.2004.03.090