Safety and Prognostic Implications of Mechanical Circulatory Support‐Assisted Transcatheter Edge‐to‐Edge Repair: The OCEAN‐Mitral Registry

Abstract

Background Transcatheter edge‐to‐edge repair of the mitral valve (M‐TEER) has demonstrated promising outcomes for patients with mitral regurgitation who are unsuitable for surgical intervention. However, the clinical implications of M‐TEER in patients requiring mechanical circulatory support (MCS) for unstable hemodynamics remains unclear. This study aimed to evaluate the outcomes of MCS‐assisted M‐TEER in critically ill patients. Methods Consecutive patients who underwent M‐TEER for significant mitral regurgitation were identified from the Japanese multicenter OCEAN‐Mitral (Optimized Catheter Valvular Intervention–Mitral) registry. All‐cause death was compared between the cohort undergoing MCS‐assisted M‐TEER and a virtual control group receiving MCS alone without undergoing M‐TEER, estimated using the Seattle Heart Failure Model. Additionally, logistic regression analysis was conducted to identify factors associated with in‐hospital death following MCS‐assisted M‐TEER. Results A total of 3764 patients were included in the analysis (mean age, 81 years; 54.9% men; 70.1% with secondary mitral regurgitation), of whom 105 underwent MCS‐assisted M‐TEER. Procedure success exceeded 95%, irrespective of MCS use. The 1‐year mortality rate in the MCS‐assisted M‐TEER group was lower than the estimated mortality rate in the virtual control group (43.2% versus 69.5%). Factors associated with in‐hospital death included frailty, inflammation, and hypoalbuminemia. In a landmark analysis starting from discharge date, there was no statistically significant difference in cardiovascular death or heart failure hospitalization between the groups with or without the use of MCS (hazard ratio, 1.45 [95% CI, 0.93–2.26]; P =0.10). Conclusions MCS‐assisted M‐TEER appears to be a viable and effective therapeutic strategy for carefully selected patients with significant mitral regurgitation and unstable hemodynamics. Registration URL: https://www.umin.ac.jp/ctr/ ; Unique identifier: UMIN‐ID: UMIN000023653

Affiliated Institutions

• Mitsui Memorial Hospital JP
• Sendai Shakai Hoken Hospital JP
• Sapporo Science Center JP
• National Cerebral and Cardiovascular Center JP
• St. Marianna University School of Medicine JP
• Gifu Heart Center JP
• Saiseikai Kumamoto Hospital JP
• Shonan Kamakura General Hospital JP
• Sakakibara Hospital JP
• Kokura Memorial Hospital JP
• Saiseikai Yokohama Eastern Hospital JP
• Teikyo University JP
• Nippon Medical School JP
• Nagoya Heart Center JP
• Kurashiki Central Hospital JP
• New Tokyo Hospital JP
• Toho University JP
• University of Toyama JP
• Toyohashi Heart Center JP
• Keio University JP

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