Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Abstract

Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.

Keywords

Hypoxia (environmental)BiologyTumor microenvironmentCancer researchCancerTumor hypoxiaCancer therapyOncologyInternal medicineTumor cellsRadiation therapyMedicineGenetics

MeSH Terms

AnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisAutophagyBiomarkersCell LineTumorDNA DamageDisease ManagementDrug ResistanceNeoplasmGene ExpressionHumansHypoxiaHypoxia-Inducible Factor 1MitochondriaNeoplasmsNeovascularizationPathologicTreatment OutcomeTumor Microenvironment

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Publication Info

Year: 2019
Type: review
Volume: 18
Issue: 1
Pages: 157-157
Citations: 1956
Access: Closed

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APA Style

                            
                                
                                    Xinming Jing, 
                                
                                    Fengming Yang, 
                                
                                    Chuchu Shao
                                
                                et al.
                            
                            (2019). 
                            Role of hypoxia in cancer therapy by regulating the tumor microenvironment. 
                            Molecular Cancer
                            , 18
                            (1)
                            , 157-157.
                            https://doi.org/10.1186/s12943-019-1089-9
                        

Identifiers

DOI: 10.1186/s12943-019-1089-9
PMID: 31711497
PMCID: PMC6844052

Data Quality

Data completeness: 90%