Reconstitution of Hematopoiesis after High-Dose Chemotherapy by Autologous Progenitor Cells Generated ex Vivo

Abstract

A small number of peripheral-blood CD34+ cells, when grown ex vivo, can supply a population of hematopoietic precursors that have the ability to restore blood formation in patients treated with high doses of chemotherapy. This method, which requires only a small volume of the patient's blood, may reduce the risk of tumor-cell contamination, circumvent the need for leukapheresis, and allow repeated cycles of high-dose chemotherapy.

Keywords

MedicineEx vivoHaematopoiesisProgenitor cellChemotherapyIn vivoProgenitorCancer researchStem cellInternal medicineBiologyCell biology

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Publication Info

Year: 1995
Type: article
Volume: 333
Issue: 5
Pages: 283-287
Citations: 370
Access: Closed

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APA Style

                            
                                
                                    Wolfram Brugger, 
                                
                                    Shelly Heimfeld, 
                                
                                    Ronald Berenson
                                
                                et al.
                            
                            (1995). 
                            Reconstitution of Hematopoiesis after High-Dose Chemotherapy by Autologous Progenitor Cells Generated ex Vivo. 
                            New England Journal of Medicine
                            , 333
                            (5)
                            , 283-287.
                            https://doi.org/10.1056/nejm199508033330503
                        

Identifiers

DOI: 10.1056/nejm199508033330503