Keywords
BiologyHeterochronyTranslation (biology)Untranslated regionGeneRegulation of gene expressionThree prime untranslated regionGeneticsRNAMessenger RNA
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Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
The heterchronic gene lin-14 controls the temporal sequence of developmental events in the Caenorhabditis elegans postembryonic cell lineage. It encodes a nuclear protein that n...
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, ...
A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
The Caenorhabditis elegans heterochronic gene lin-14 generates a temporal gradient of the LIN-14 proteins to control stage-specific patterns of cell lineage during development. ...
Heterochronic Mutants of the Nematode <i>Caenorhabditis elegans</i>
Mutations in the Caenorhabditis elegans genes lin-14 , lin-28 , and lin-29 cause heterochronic developmental defects: the timing of specific developmental events in several tiss...
The <i>C. elegans</i> microRNA <i>let-7</i> binds to imperfect <i>let-7</i> complementary sites from the <i>lin-41</i> 3′UTR
Caenorhabditis elegans let-7 , a founding member of the microRNA family, is predicted to bind to six sites in the 3′UTR of the mRNA of its target gene, lin-41 , to down-regulate...
Publication Info
- Year
- 1993
- Type
- article
- Volume
- 75
- Issue
- 5
- Pages
- 855-862
- Citations
- 4171
- Access
- Closed
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Cite This
Bruce Wightman,
Ilho Ha,
Gary Ruvkun
(1993).
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans.
Cell
, 75
(5)
, 855-862.
https://doi.org/10.1016/0092-8674(93)90530-4
Identifiers
- DOI
- 10.1016/0092-8674(93)90530-4