Abstract

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among phospholipids in that its head group can be phosphorylated at multiple free hydroxyls. Several phosphorylated derivatives of phosphatidylinositol, collectively termed phosphoinositides, have been identified in eukaryotic cells from yeast to mammals. Phosphoinositides are involved in the regulation of diverse cellular processes, including proliferation, survival, cytoskeletal organization, vesicle trafficking, glucose transport, and platelet function. The enzymes that phosphorylate phosphatidylinositol and its derivatives are termed phosphoinositide kinases. Recent advances have challenged previous hypotheses about the substrate selectivity of different phosphoinositide kinase families. Here we re-examine the pathways of phosphoinositide synthesis and the enzymes involved.

Keywords

PhosphatidylinositolKinasePhosphoinositide 3-kinaseCell biologyPhosphorylationBiologyBiochemistryChemistryProtein kinase B

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Publication Info

Year
1998
Type
review
Volume
67
Issue
1
Pages
481-507
Citations
1344
Access
Closed

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David A. Fruman, Rachel Meyers, Lewis C. Cantley (1998). PHOSPHOINOSITIDE KINASES. Annual Review of Biochemistry , 67 (1) , 481-507. https://doi.org/10.1146/annurev.biochem.67.1.481

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DOI
10.1146/annurev.biochem.67.1.481