Peptide Antibiotics and Their Role in Innate Immunity

1995 Annual Review of Immunology 1,608 citations

Abstract

CONTENTS INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 FIVE CHEMICALLY DIFFERENT GROUPS OF PEPTIDE ANTIBIOTICS . . . . . . . . . . .. 63 Linear, Mostly Helical, Peptides Without Cys, With or Without a Hinge . . . . . . . . . . . . . . . 63 Linear Pep tides Without Cys and with a High Proportion of Certain Residues . . . . . . . . . 67 Antibacterial Peptides with One Disulfide Bond . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 Peptides with Two or More S-S Bonds Giving Mainly or Only fJ-Sheet Structures. . . . . . . 69 Antibacterial Peptides Derivedfrom Larger Polypeptides with Other Known Functions . . 72 ANTIBACTERIAL PROTEINS AND ACTIVE FRAGMENTS OF SUCH PROTEINS . . . . 73

Keywords

BiologyInnate immune systemAntibioticsImmunityImmunologyPeptideMicrobiologyImmune systemBiochemistry

Affiliated Institutions

Related Publications

Innate immunity and the normal microflora

This paper discusses the following ten subtitles with the contents indicated. 1. To meet a microbe: discusses the four alternatives in host-microbe interactions. 2. Receptors an...

2000 Immunological Reviews 354 citations

Toll-like Receptor Signaling

The innate immune response in vertebrates is the first line of defense against invading microorganisms. The main players in innate immunity are phagocytes such as neutrophils, m...

2003 Journal of Biological Chemistry 1482 citations

Publication Info

Year
1995
Type
review
Volume
13
Issue
1
Pages
61-92
Citations
1608
Access
Closed

External Links

Social Impact

Social media, news, blog, policy document mentions

Citation Metrics

1608
OpenAlex

Cite This

Hans G. Boman (1995). Peptide Antibiotics and Their Role in Innate Immunity. Annual Review of Immunology , 13 (1) , 61-92. https://doi.org/10.1146/annurev.iy.13.040195.000425

Identifiers

DOI
10.1146/annurev.iy.13.040195.000425