Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es; Mariëlle van Gijn; Orbicia Riccio; Maaike van den Born; Marc Vooijs; Harry Begthel; Miranda Cozijnsen; Sylvie Robine; Doug J. Winton; Freddy Radtke; Hans Clevers

doi:10.1038/nature03659

Keywords

CryptWnt signaling pathwayNotch signaling pathwayGoblet cellBiologyCell biologyProgenitor cellCancer researchStem cellCellular differentiationPaneth cellHES1EpitheliumPathologySmall intestineSignal transductionEndocrinologyGeneticsMedicineGene

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Publication Info

Year: 2005
Type: article
Volume: 435
Issue: 7044
Pages: 959-963
Citations: 1496
Access: Closed

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APA Style

                            
                                
                                    Johan H. van Es, 
                                
                                    Mariëlle van Gijn, 
                                
                                    Orbicia Riccio
                                
                                et al.
                            
                            (2005). 
                            Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. 
                            Nature
                            , 435
                            (7044)
                            , 959-963.
                            https://doi.org/10.1038/nature03659
                        

Identifiers

DOI: 10.1038/nature03659