New gene functions in megakaryopoiesis and platelet formation

Christian Gieger; Aparna Radhakrishnan; Ana Cvejic; Weihong Tang; Eleonora Porcu; Giorgio Pistis; Jovana Serbanovic‐Canic; Ulrich Elling; Alison H. Goodall; Yann Labrune; Lorna M. Lopez; Reedik Mägi; Stuart Meacham; Yukinori Okada; Nicola Pirastu; Rossella Sorice; Alexander Teumer; Katrin Voß; Weihua Zhang; Ramiro Ramírez‐Solis; Joshua C. Bis; David Ellinghaus; Martin Gögele; Jouke‐Jan Hottenga; Claudia Langenberg; Péter Kovács; Paul F. O’Reilly; So-Youn Shin; Tõnu Esko; Jaana Hartiala; Stavroula Kanoni; Federico Murgia; Afshin Parsa; Jonathan Stephens; Pim van der Harst; C. Ellen van der Schoot; Hooman Allayee; Antony Attwood; Beverley Balkau; François Bastardot; Saonli Basu; Sebastian E. Baumeister; Ginevra Biino; Lorenzo Bomba; Amélie Bonnefond; François Cambien; John C. Chambers; Francesco Cucca; Pio D’Adamo; Gail Davies; Rudolf A. de Boer; Eco J. C. de Geus; Angela Döring; Paul Elliott; Jeanette Erdmann; David M. Evans; Mario Falchi; Wei Feng; Aaron R. Folsom; Ian H. Frazer; Quince Gibson; Nicole L. Glazer; Christopher J. Hammond; Anna-Liisa Hartikainen; Susan R. Heckbert; Christian Hengstenberg; Micha Hersch; Thomas Illig; Ruth J. F. Loos; Jennifer Jolley; Kay‐Tee Khaw; Brigitte Kühnel; Marie-Christine Kyrtsonis; Vasiliki Lagou; Heather Lloyd-Jones; Thomas Lumley; Massimo Mangino; Andrea Maschio; Irene Mateo Leach; Barbara McKnight; Yasin Memari; Braxton D. Mitchell; Grant W. Montgomery; Yusuke Nakamura; Matthias Nauck; Gerjan Navis; Ute Nöthlings; Ilja M. Nolte; David J. Porteous; Anneli Pouta; Peter P. Pramstaller; Janne Pullat; Susan M. Ring; Jerome I. Rotter; Daniela Ruggiero; Aimo Ruokonen; Cinzia Sala; Nilesh J. Samani; Jennifer Sambrook; David Schlessinger

doi:10.1038/nature10659

Keywords

BiologyGenome-wide association studyGeneGene regulatory networkDrosophila melanogasterPlateletMegakaryocyteGene silencingComputational biologyGeneticsFunctional genomicsCell typeGene expressionGenomeCellGenomicsHaematopoiesisSingle-nucleotide polymorphismStem cellImmunology

Affiliated Institutions

Related Publications

Should myeloid and lymphoid neoplasms with <i><scp>PCM</scp>1‐<scp>JAK</scp>2</i> and other rearrangements of <i><scp>JAK</scp>2</i> be recognized as specific entities?

Barbara J. Bain , Shahzaib Ahmad

Summary Since the publication of the 2001 and 2008 World Health Organization classifications of tumours of haematopoietic and lymphoid tissues, there has been an increasing move...

2014 British Journal of Haematology 83 citations

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

Danielle Welter , Jacqueline MacArthur , Joannella Morales +8 more

The National Human Genome Research Institute (NHGRI) Catalog of Published Genome-Wide Association Studies (GWAS) Catalog provides a publicly available manually curated collectio...

2013 Nucleic Acids Research 2876 citations

Mapping the Genetic Architecture of Gene Expression in Human Liver

Eric E. Schadt , Cliona Molony , Eugene Chudin +28 more

Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce change...

2008 PLoS Biology 924 citations

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Nick Craddock , Matthew E. Hurles , Niall J. Cardin +97 more

Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common di...

2010 Nature 809 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

Publication Info

Year: 2011
Type: review
Volume: 480
Issue: 7376
Pages: 201-208
Citations: 420
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

New gene functions in megakaryopoiesis and platelet formation

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

420

OpenAlex

Cite This

APA Style

                            
                                
                                    Christian Gieger, 
                                
                                    Aparna Radhakrishnan, 
                                
                                    Ana Cvejic
                                
                                et al.
                            
                            (2011). 
                            New gene functions in megakaryopoiesis and platelet formation. 
                            Nature
                            , 480
                            (7376)
                            , 201-208.
                            https://doi.org/10.1038/nature10659
                        

Identifiers

DOI: 10.1038/nature10659