Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

Abstract

Recording many neurons for a long time The ultimate aim of chronic recordings is to sample from the same neuron over days and weeks. However, this goal has been difficult to achieve for large populations of neurons. Steinmetz et al. describe the development and testing of Neuropixels 2.0. This new electrophysiological recording tool is a miniaturized, high-density probe for both acute and long-term experiments combined with sophisticated software algorithms for fully automatic post hoc computational stabilization. The technique also provides a strategy for extending the number of recorded sites beyond the number of available recording channels. In freely moving animals, extremely large numbers of individual neurons could thus be followed and tracked with the same probe for weeks and occasionally months. Science , this issue p. eabf4588

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Affiliated Institutions

• ATLAS Neuroengineering (Belgium) BE
• KU Leuven BE
• Vlaams Instituut voor Biotechnologie BE
• University of Leicester GB
• Champalimaud Foundation PT
• National Hospital for Neurology and Neurosurgery GB
• University College London GB
• Janelia Research Campus US
• Neuroelectronics Research Flanders BE
• Wolfson Foundation GB
• IMEC BE
• University of Washington US
• Sainsbury Laboratory GB
• Norwegian University of Science and Technology
• Howard Hughes Medical Institute US
• VIB-KU Leuven Center for Brain & Disease Research BE

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