Abstract

In patients with amnestic MCI who were followed longitudinally, the early changes of Alzheimer disease were present. The NFTs were slightly more prominent than beta-amyloid peptide deposition in the progression from normal to MCI to EAD. Ventromedial temporal lobe NFTs probably represent the substrate for memory decline in MCI. From a neuropathologic perspective, it appears that amnestic MCI is, in reality, EAD.

Keywords

SubiculumTemporal lobeNeocortexAmygdalaAlzheimer's diseaseEntorhinal cortexPsychologySenile plaquesHippocampusTemporal cortexCerebral cortexInternal medicineNeurosciencePathologyMedicineEpilepsyDiseaseDentate gyrus

Affiliated Institutions

Related Publications

Publication Info

Year
2006
Type
article
Volume
63
Issue
1
Pages
38-38
Citations
459
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

459
OpenAlex

Cite This

William R. Markesbery, Frederick A. Schmitt, Richard J. Kryscio et al. (2006). Neuropathologic Substrate of Mild Cognitive Impairment. Archives of Neurology , 63 (1) , 38-38. https://doi.org/10.1001/archneur.63.1.38

Identifiers

DOI
10.1001/archneur.63.1.38