Abstract
Macromolecular interactions (i.e. protein-protein or DNA/RNA-protein interactions) play important cellular roles, including cellular communication and programmed cell death. Small-molecule chemical probes are crucial for dissecting these highly organized interactions, for mapping their function at the molecular level and developing new therapeutics. The lack of ideal chemical probes required to understand macromolecular interactions is the missing link in the next step of dissecting such interactions. Unfortunately, the classical combinatorial-chemistry community has not successfully provided the required probes (i.e. natural product inspired chemical probes that are rich in stereochemical and three-dimensional structural diversity) to achieve these goals. The emerging area of diversity-oriented synthesis (DOS) is beginning to provide natural product-like chemical probes that may be useful in this arena.
Keywords
Chemical spaceChemical biologyNatural productMacromoleculeFunction (biology)Computational biologySmall moleculeProtein functionChemistryNanotechnologyBiologyDrug discoveryBiochemistryCell biologyMaterials scienceGene
MeSH Terms
Biological FactorsCombinatorial Chemistry TechniquesDrug DesignMacromolecular SubstancesMolecular StructureStereoisomerism
Affiliated Institutions
Related Publications
Orthogonal Multipolar Interactions in Structural Chemistry and Biology
Abstract The past few decades of molecular recognition studies have greatly enhanced our knowledge on apolar, ion–dipole, and hydrogen‐bonding interactions. However, much less a...
Inhibition of Myelin Membrane Sheath Formation by Oligodendrocyte-derived Exosome-like Vesicles
Myelin formation is a multistep process that is controlled by a number of different extracellular factors. During the development of the central nervous system (CNS), oligodendr...
All-atom empirical force field for nucleic acids: I. Parameter optimization based on small molecule and condensed phase macromolecular target data
Empirical force-field calculations on biological molecules represent an effective method to obtain atomic detail information on the relationship of their structure to their func...
OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space
We report on the development and validation of the OPLS4 force field. OPLS4 builds upon our previous work with OPLS3e to improve model accuracy on challenging regimes of drug-li...
Protein Folding Requires Crowd Control in a Simulated Cell
Macromolecular crowding has a profound effect upon biochemical processes in the cell. We have computationally studied the effect of crowding upon protein folding for 12 small do...
Publication Info
- Year
- 2005
- Type
- review
- Volume
- 9
- Issue
- 3
- Pages
- 240-247
- Citations
- 95
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
95
OpenAlex
0
Influential
85
CrossRef
Cite This
Ayub Reayi,
Prabhat Arya
(2005).
Natural product-like chemical space: search for chemical dissectors of macromolecular interactions.
Current Opinion in Chemical Biology
, 9
(3)
, 240-247.
https://doi.org/10.1016/j.cbpa.2005.04.007
Identifiers
- DOI
- 10.1016/j.cbpa.2005.04.007
- PMID
- 15939325