Keywords
BiologyPoint mutationMutationTransmembrane proteinOncogeneDomain (mathematical analysis)GeneticsTransmembrane domainCancer researchComputational biologyCell biologyGeneReceptorCell cycle
Affiliated Institutions
Related Publications
Cdc53p Acts in Concert with Cdc4p and Cdc34p To Control the G<sub>1</sub>-to-S-Phase Transition and Identifies a Conserved Family of Proteins
Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4,...
THE UBIQUITIN SYSTEM
The selective degradation of many short-lived proteins in eukaryotic cells is carried out by the ubiquitin system. In this pathway, proteins are targeted for degradation by cova...
UBIQUITIN-DEPENDENT PROTEIN DEGRADATION
▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein modification by the polypeptide ubiquitin. These include key transitions in the cell cy...
Neu-Protein Overexpression in Breast Cancer
Amplification of the neu proto-oncogene in breast cancer has been reported to correlate with the presence of lymph-node metastases and with a poor prognosis. We describe a metho...
Regulation ofp53downstream genes
The p53 tumor suppressor is the most commonly mutated gene in human cancer. p53 protein is stabilized in response to different checkpoints activated by DNA damage, hypoxia, vira...
Publication Info
- Year
- 1986
- Type
- article
- Volume
- 45
- Issue
- 5
- Pages
- 649-657
- Citations
- 1012
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1012
OpenAlex
Cite This
Cornelia I. Bargmann,
Mien‐Chie Hung,
Robert A. Weinberg
(1986).
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.
Cell
, 45
(5)
, 649-657.
https://doi.org/10.1016/0092-8674(86)90779-8
Identifiers
- DOI
- 10.1016/0092-8674(86)90779-8