Abstract

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

Keywords

Mesenchymal stem cellStem cell transplantation for articular cartilage repairStem cellAdult stem cellClinical uses of mesenchymal stem cellsAmniotic stem cellsBiologyCell biologyBone marrowMultipotent Stem CellEndothelial stem cellIn vitroImmunologyProgenitor cellGenetics

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Publication Info

Year
1999
Type
article
Volume
284
Issue
5411
Pages
143-147
Citations
20837
Access
Closed

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Mark F. Pittenger, Alastair M. Mackay, Stephen C. Beck et al. (1999). Multilineage Potential of Adult Human Mesenchymal Stem Cells. Science , 284 (5411) , 143-147. https://doi.org/10.1126/science.284.5411.143

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DOI
10.1126/science.284.5411.143